생물정보학 세미나 공지

 

 

  

서울대학교 생물정보연구소와 생물정보학 협동과정 공동 주최로 특별 세미나를 아래와 같이 개최하오니, 많은 참여 바랍니다.

 

 

일시: 2013. 7. 25.(목) 11:00

연사: 황태현 교수 (University of Texas Southwestern Medical Center)

장소: 25동 411호

 

Title: Cancer Genome Analyses to Personalize Treatment: From Microarray to Next-generation sequencing data

 

 

Abstract:

Recently developed high-throughput biotechnologies allow mapping of the complete genome sequence, and molecular and cellular features of human cancer. Finding associations between human cancer and various ‘omics data including gene expression, DNA copy numbers, and next-generation sequencing data can shed light on the molecular and cellular mechanisms underlying human cancer, but calls for new computational approaches for its analysis.

To address these challenges, we have developed and applied computational approaches to integrate various types of genomic data with prior knowledge (e.g., pathway, protein-protein interaction network and etc.) for biomarker discovery, cancer outcome prediction and patient stratification. In this talk, I will present our recent efforts (1) to integrate genomic data (e.g., gene expression, copy number, and mutation) with pathway to identify a) patient subgroups having different survival outcomes and b) pathways disrupted by somatic mutations in human cancer, (2) to estimate heterogeneity of cell populations linked to therapy resistance next-generation sequencing data. These methods and analyses can provide a systematic understanding of the mechanisms of cancer development and progression, and thus suggest the potential for a guide to targeted therapy in cancer patients. In addition, I will discuss lessons learned and new challenges in cancer genomics.

 

 

 

 

Bio:

 

Research Interests : Computational Biology, Machine Learning, Data Mining, and Statistical Methods

Education

• University of Minnesota Twin Cities, USA Mar. 2011 - Ph.D., Department of Computer Science and Engineering
• Inha University, KOREA Aug. 2005- M.S. (transferred), Department of Computer Science and Engineering
• Inha University, KOREA Feb. 2004 - B.E., Department of Computer Science and Engineering

Research Experience

• Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, USA - Assistant Professor Jan. 2013 - current
• Masonic Cancer Center, University of Minnesota Twin Cities, USA - Principal Investigator, Research Scientist Mar. 2011 - Jan. 2013
• Genentech, Inc., USA - Research Intern Jun. 2010- Sept. 2010
• University of Minnesota Twin Cities, USA - Research Assistant Jun. 2007 - present
• Inha University, KOREA - Research Assistant Mar. 2004 - Jun. 2005

 

서울대학교 생물정보연구소

협동과정 생물정보학전공 공동주최