생물정보학 세미나 공지

 

 

  

서울대학교 생물정보연구소와 생물정보학 협동과정 공동 주최로 특별 세미나를 아래와 같이 개최하오니, 많은 참여 바랍니다.

 

 

일시: 2013. 9. 25.(수) 11:00

연사: 한미라 교수 (University of Nevada Las Vegas, school of life science)

장소: 25동 411호

 

Title: Duplication, loss and transposition of genes in Drosophila genomes

 

 

Abstract:

Variation in genome structure appears to have a significant role, complementary to that of sequence divergence, in explaining the phenotypic difference across species. However, studies on large-scale structural variation are still at an early stage when compared to the fifty years of research accumulated on sequence variation. In the first part of the talk, I expand the existing models of gene duplication and loss and apply it to the 12 genomes of Drosophila. I show that there are heterogeneous rates of gene gain and loss across different gene families and significant changes in gene family size in specific lineages. In the second part of the talk, I use a novel method to identify transposed genes across multiple genomes. In doing so, I make new observations regarding the evolution of transposed genes, including the faster sequence evolution in transposed genes compared to the original copies, bias in the direction of transpositions within the genome, and overrepresentation of specific functions among transposed genes. Using bioinformatics, I investigate how genomes evolve through gene duplication, loss, and transposition.

 

 

 

Bio:

 

I. Education:

• 2005-2011 Ph.D., Informatics, Indiana University, Bloomington, IN
• 1997-2002 B.S., Computer Science and Engineering, Seoul National University, South Korea

II. Appointments:

• 2011-current Postdoctoral, National Evolutionary Synthesis Center, Duke University, Durham, NC

III. Representative publications (*Corresponding author)

• 1. Han, M.V.*, G.W.C. Thomas, and M.W. Hahn, Estimating gene gain and loss rates in the presence of error in genome assembly and annotation using CAFE 3, Molecular Biology and Evolution. 2013. 30(8):1987-97
• 2. Han, M. V.* Characterizing gene movements between chromosomes in Drosophila. Fly. 2012. 6: 121–- 125.
• 3. Han, M.V.* and M.W. Hahn, Inferring the history of interchromosomal gene transposition in Drosophila using n-dimensional parsimony, Genetics. 2012. 190(2):813-825
• 4. Moyle, L.C., C.D. Muir, M.V. Han, and M.W. Hahn, The Contribution of Gene Movement to the “"Two Rules of Speciation”", Evolution. 2010. 64(6):1541-1557
• 5. Meisel, R.P. M.V. Han, and M.W. Hahn, A Complex Suite of Forces Drives Gene Traffic from Drosophila X Chromosomes, Genome Biology and Evolution. 2009. 2009:176-188
• 6. Han, M.V., J.P. Demuth, C.L. McGrath, C. Casola, and M.W. Hahn, Adaptive evolution of young gene duplicates in mammals, Genome Research. 2009. 19:859-867
• 7. Han, M.V. and M.W. Hahn, Identifying Parent-Daughter Relationships Among Duplicated Genes, Pacific Symposium on Biocomputing. 2009. 14:114-125
• 8. Hahn, M.W., M.V. Han, and S.-G. Han, Gene Family Evolution across 12 Drosophila Genomes. PLoS Genetics, 2007. 3(11):e197
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서울대학교 생물정보연구소

협동과정 생물정보학전공 공동주최