서울대학교 생물정보연구소와 생물정보학 협동과정 공동 주최로 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.

일시: 2017년 10월 12일 목요일 오전 11시

연사: 이대호 (가천대 길병원 내분비대사내과)

장소: 서울대학교 25동 411호

Title

Clinical perspectives of metagenome researches on metabolic diseases and complications

Abstract

The gut microbiota consists of over 10 trillion microbial cells, which carry greater than 100-fold more genes than the human genome, and is a primary source of thousands of small molecules and other bioactive compounds. The human gut microbiota also contains about 1000 different bacterial species with defined functions. Importantly, gut microbes communicate with the human host in either a symbiotic or deleterious fashion, keeping the optimal state of host health, but also being implicated in the pathogenesis of numerous metabolic diseases, such as obesity, diabetes, chronic kidney disease and cardiovascular diseases and cancers. Previous studies have shown a link between the gut microbiota and human metabolic health, with transferability of insulin resistance phenotypes through faecal microbiome transplants. These effects may partly be mediated through the microbial metabolites. Serum levels of amino acids, most consistently the branched-chain amino acids (BCAAs), triacylglycerols with low carbon number and double bonds, as well as specific membrane phospholipids, have previously been associated with insulin resistance and risk of metabolic diseases and cardiovascular complications. In light of the critical role of a molecular dialog in maintaining a productive mutualism, the community of researchers studying the symbiosis between humans and their microbiota has begun moving from a focus on ‘who’s there’ to ‘what are they doing’. Thus, advances in metagenomics and metabolomics have led to the discovery of thousands of microbe-derived small molecules as well as the genes associated with their production. We have ~150 subjects’ metagenome data analyzed in serum and urine samples from normal control, patients with type 2 diabetes mellitus (T2DM), and T2DM patients with progressive diabetic kidney disease (DKD). These data may be useful for finding a metagenomics marker for rapidly progressive DKD and for understanding pathophysiological association between metabolic diseases/complications and microbiota.

Education

전남대학교 의과대학 학사, 석사, 의학박사

Experience

1991-2000 전남대학교병원 내과 전공의, 내분비대사내과 Clinical fellow

2003-2013 제주의대 교수

2007-2009 미국하버드 의대 연수(Visiting Scholar)

2013-2016 원광의대 교수

2016~현재 가천대 길병원 내분비대사내과 교수

연구중심병원 육성 R&D 사업 5세부 책임

대한당뇨병학회 연구이사

서울대학교 생물정보연구소

생물정보학 협동과정 공동주최