생물정보학 세미나 공지

서울대학교 생물정보연구소와 생물정보학 협동과정 공동 주최로 특별 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.

일시: 2013. 5. 16.(목) 14:00

연사: Luonan Chen 교수

      (Executive Director and Professor, Key Laboratory of Systems Biology, Chinese Academy of Sciences)

장소: 25동 411호

Title: Analysis of Complex Diseases based on Network Activities

Abstract: Synergistic interactions among transcription factors (TFs) and their cofactors collectively determine gene expression in complex biological systems. In this work, we develop a novel graphical model, called Active Protein-Gene (APG) network model, to quantify regulatory signals of transcription in complex biomolecular networks through integrating both TF upstream-regulation and downstream-regulation high-throughput data. Firstly, we theoretically and computationally demonstrate the effectiveness of APG by comparing with the traditional strategy based only on TF downstream-regulation information. We then apply this model to study spontaneous type 2 diabetes and cancers. Our biological experiments validate the theoretical results. APG model provides theoretical basis to quantitatively elucidate transcriptional regulation by modelling TF combinatorial interactions and exploiting multilevel high-throughput information.

Bio: Dr. Luonan Chen received the M.E. and Ph.D. degrees in the electrical engineering, from Tohoku University, Sendai, Japan, in 1988 and 1991, respectively. From 1997, he was an associate professor of the Osaka Sangyo University, Osaka, Japan, and then a full Professor. Since 2010, he has been an Executive Director and Professor at Key Laboratory of Systems Biology, Chinese Academy of Sciences, and also a research professor at Institute of Industrial Science, The University of Tokyo. He was the founding director of Institute of Systems Biology, Shanghai University, and serves as Chair of Technical Committee of Systems Biology at IEEE SMC Society, and is also the founding president of Computational Systems Biology Society of ORS China. His fields of interest are systems biology, bioinformatics, and nonlinear dynamics. He serves as editor or editorial board member for many systems biology related journals, e.g. BMC Systems Biology, IEEE/ACM Trans. on Computational Biology and Bioinformatics, J. Royal Society Interface, IET Systems Biology, Journal of Theoretical Biology, Mathematical Biosciences, Int. J. of Systems and Synthetic Biology, Journal of Molecular Cell Biology, and J. of Systems Science and Complexity. In recent five years, he published over 100 journal papers and two monographs (books) in the area of systems biology.

서울대학교 생물정보연구소

생물정보학 협동과정 공동주최