생물정보학 세미나 공지

  

 

서울대학교 생물정보연구소 및 생물정보학 협동과정 공동 주최로 특별 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.

 

일시: 2012년 1월 17일(화) 11:00

연사: 백은옥 교수(서울시립대학교)

장소: 25동 411호 

 

 

MODa: multi-blind modification search algorithm for tandem mass spectrometry

 

With great biological interest in post-translational modifications (PTMs), various approaches have been introduced to identify PTMs using tandem mass spectrometry (MS/MS). Recent developments for PTM identification have focused on an unrestrictive approach that searches MS/MS spectra for all known and possibly even unknown types of PTMs at once. However, the resulting expanded search space requires much longer search time and also increases the number of false positives (incorrect identifications) and false negatives (missed true identifications), thus creating a bottleneck in high throughput analysis. Here we introduce MODa, a novel ‘multi-blind’ spectral alignment algorithm that allows for fast unrestrictive PTM searches with no limitation on the number of modifications per peptide while featuring over an order of magnitude speedup in relation to existing approaches. We demonstrate the sensitivity of MODa on Human shotgun proteomics data where it reveals multiple mutations, a wide range of modifications (including glycosylation) and finds evidence for several putative novel modifications. Based on the reported findings we argue that MODa’s efficiency and sensitivity make it the first unrestrictive search tool with the potential to fully replace conventional restrictive identification of proteomics mass spectrometry data.

 

Bio:

 

Research Interests	Bioinformatics: Computational Mass Spectrometry, Systems Biology, Bio-ontology Artificial Intelligence: Knowledge Representation, Formal Methods, Machine Learning, Information Retrieval, Natural Language Understanding,
Education	Stanford University,Stanford, CA June, 1991 - Ph.D.,ComputerScience Seoul NationalUniversity, Seoul, Korea February, 1985 - B.S.,ComputerEngineering
Professional Experience	2001 – present : University of Seoul, Seoul, Korea - Professor 2010. 4 – 2010. 6 : SK Corp., Seoul, Korea - TechnologyAdvisor 2008-2009 : University of California San Diego, San Diego, CA - VisitingResearcher 2006. 12 – 2007. 8 : SK Telecommunications, Seoul, Korea - TechnologyAdvisor 1996 – 2000 : LG Corporate Institute of Technology, Seoul, Korea - SeniorResearchEngineer 1992 – 1995 : Research Inst. of Adv. Comp. Tech., Seoul Nat’l Univ., Seoul, Korea - Post-doc.&ResearchScientist 1992 – 1995 : Dept. of Computer Engineering, SeoulNat’lUniv.,Seoul, Korea - Lecturer

 

 

 

서울대학교 생물정보연구소

 

자연과학대학 생물정보학 협동과정 공동주최