세미나 안내
How can we enhance treatment responses of anti-PD-1?
작성자
admbioinfo
작성일
2018-10-29
조회
41
서울대학교 생물정보연구소 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.
일시: 2018년 11월 19일 오전 10시
연사: 신의철 (Eui-Cheol Shin)
장소: 서울대학교 220동 625호 대회의실
제목: How can we enhance treatment responses of anti-PD-1?
초록:
During immune responses, antigen-specific T cells are regulated by various mechanisms including inhibitory receptors and regulatory T cells to avoid excessive and persistent immune responses. These regulatory mechanisms, called ‘immune checkpoint’, suppress T cell responses particularly in chronic viral infection and cancer, in which viral antigens or tumor antigens persist for a longtime, and lead to T cell exhaustion in patients with chronic viral infection or cancer. Among them, cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) are the most well-known receptors and have been targeted for drug development. As a result, anti-CTLA-4 and anti-PD-1 (or anti-PD-L1) blocking antibodies were developed for cancer treatment and known as ‘immune checkpoint inhibitors’. However, anti-CTLA-4 and anti-PD-1 (or anti-PD-L1) blocking antibodies fail to control tumors in a significant proportion of cancer patients. Therefore, it is an important question how the coverage of immune checkpoint inhibitors can be extended to the majority of cancer patients who do not have control or regression of their cancer. In this lecture, strategies to improve treatment responses of anti-PD-1 will be discussed, including novel immuno-modulators and biomarkers predicting treatment responses.
연사이력:
학 력: 1990-1996: 연세대학교 의과대학 의학사 (M.D.)
1996-2001: 연세대학교 대학원 의학박사 (Ph.D., 미생물학/면역학)
경 력: 2002-2007: 미국 NIH, NIDDK, Postdoctoral Fellow
2007-2013: KAIST 의과학대학원 조교수 (면역 및 감염질환 연구실)
2013-현재: KAIST 의과학대학원 부교수 (면역 및 감염질환 연구실)
2017-현재: KAIST 석좌교수
2011-2012: 대한면역학회 백신연구회 회장
2013-현재: 대한면역학회 편집부위원장
2014-2017: 대한백신학회 학술이사
2018-현재: 대한바이러스학회 학술이사
2017-현재: Member, Immunology working group,
International Coalition to Eliminate Hepatitis B Virus (ICE-HBV)
2018-현재: Member, HCV Conference International Organizing Committee
1996-2001: 연세대학교 대학원 의학박사 (Ph.D., 미생물학/면역학)
경 력: 2002-2007: 미국 NIH, NIDDK, Postdoctoral Fellow
2007-2013: KAIST 의과학대학원 조교수 (면역 및 감염질환 연구실)
2013-현재: KAIST 의과학대학원 부교수 (면역 및 감염질환 연구실)
2017-현재: KAIST 석좌교수
2011-2012: 대한면역학회 백신연구회 회장
2013-현재: 대한면역학회 편집부위원장
2014-2017: 대한백신학회 학술이사
2018-현재: 대한바이러스학회 학술이사
2017-현재: Member, Immunology working group,
International Coalition to Eliminate Hepatitis B Virus (ICE-HBV)
2018-현재: Member, HCV Conference International Organizing Committee
Editorial Board: Clinical & Experimental Medicine, Frontiers in Microbiology
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