서울대학교 생물정보학 협동과정 주최로 세미나를 아래와 같이 열고자 하오니, 많은 참여 바랍니다.
일시: 2017년 12월 07일 목요일 오전 11시
연사: 이호선 (국립과학수사연구소)
장소: 서울대학교 25동 411호
Title : Interaction between age at menarche and genetic polymorphisms on traits of metabolic syndrome
Abstract : Early menarche has been associated with increased risk of metabolic syndrome (MetS). Although MetS has a significant genetic component, limited evidence, to date, supports a common genetic background underlying an association of age of menarche and MetS. Therefore, we evaluated previous GWAS-identified genetic variants for interactions between specific SNPs and age at menarche. At first, we identified the risk of MetS incidence was significantly increased only at 12 ≤ years of age at menarche. Women with early menarche (≤12 years) also had significantly higher levels of triglycerides and waist circumference. For gene-environment interaction, we identified 2 SNPs located on chromosome 2 (intergenic to the SCG2) were associated with triglycerides including the genetic interaction with age at menarche. These two SNPs were not associated with triglycerides in a main effect only model. These findings may help us understand the role of age at menarche on development of MetS, and gene-environment interactions that confer MetS susceptibility.
학 력
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Year
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Degree
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Major
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Institution
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Town
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Country
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2006-2010
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PhD
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Toxicology
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Sookmyung women’s university
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Seoul
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South Korea
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2002-2006
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BS
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Pharmacy
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Sookmyung women’s university
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Seoul
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South Korea
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경 력
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Period
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Organization
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Title
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2017-present
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National Forensic Service
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Researcher
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2015-2017
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Seoul National University
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Research professor
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2014-2015
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Sookmyung women’s university
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Research professor
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2010-2013
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International Agency for Research on Cancer-WHO
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Postdoc fellow
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Selected Publications
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Authors
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Year
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Title
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Journal
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Lee HS, Park TS
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2017
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Pathway-Driven Approaches of Interaction between Oxidative Balance and Genetic Polymorphism on Metabolic Syndrome.
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Oxid Med Cell Longev. 2017;2017:6873197
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Lee HS
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2015
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Impact of Maternal Diet on the Epigenome during In Utero Life and the Developmental Programming of Diseases in Childhood and Adulthood.
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Nutrients. 2015 Nov 17;7(11):9492-507
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Lee HS, Barraza-Villarreal A, Biessy C, Duarte-Salles T, Sly PD, Ramakrishnan U, Rivera J, Herceg Z, Romieu I.
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2014
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Dietary supplementation with polyunsaturated fatty acid during pregnancy modulates DNA methylation at IGF2/H19 imprinted genes and growth of infants.
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Physiol Genomics. 2014 Dec 1;46(23):851-7
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Lee HS, Herceg Z
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2014
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The epigenome and cancer prevention: A complex story of dietary supplementation
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Cancer Lett. 2014 Jan 28;342(2):275-84.
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Lee HS, Barraza-Villarreal A, Hernandez-Vargas H, Sly PD, Biessy C, Ramakrishnan U, Romieu I, Herceg Z
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2013
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Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study
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Am J Clin Nutr. 2013 Aug;98(2):480-7
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서울대학교 생물정보학 협동과정 주최
